Polynucleotides for Skin Health and Rejuvenation: The Science Behind Natural Skin Repair

derma 2 bio box with small bottles

In pursuing youthful, vibrant skin, people constantly seek solutions that promise long-lasting health and rejuvenation. From innovative skincare products to cutting-edge dermatological treatments, the quest for anti-ageing miracles is never-ending. However, an emerging star in the skincare industry, polynucleotides, has started to make waves due to its natural regenerative properties. These compounds are gaining attention as they offer promising skin-repairing, anti-ageing, and rejuvenation benefits.

Polynucleotides are backed by robust scientific research. They have been used in medicine for decades, particularly in tissue regeneration and wound healing. Their role in enhancing skin health and reversing signs of ageing is drawing the spotlight.

What Are Polynucleotides?

Polynucleotides are natural biopolymers composed of long chains of nucleotides, which are the building blocks of DNA and RNA. These molecules are fundamental to biological processes such as cell repair, growth, and regeneration. In skin care, polynucleotides are powerful agents that stimulate tissue repair, promote cellular activity, and enhance skin elasticity.

Given their biological significance, polynucleotides provide profound therapeutic benefits when applied to the skin. They improve the skin’s natural ability to repair itself, especially after exposure to environmental stressors like UV radiation, pollution, and the natural ageing process.

How Do Polynucleotides Benefit Skin Health?

The skin’s regenerative capacity declines as we age, leading to visible signs such as wrinkles, sagging, and dehydration. Polynucleotides offer a unique approach to rejuvenating the skin through several key mechanisms.

1. Enhanced Skin Repair and Regeneration

Polynucleotides promote skin repair by stimulating fibroblast activity—cells that produce collagen and elastin, both critical for maintaining skin structure. This helps to restore the skin’s firmness and elasticity, reducing the appearance of fine lines and wrinkles. Since polynucleotides enhance tissue regeneration, they are particularly beneficial for skin that has been damaged by acne scars, sun exposure, or general wear and tear.

2. Deep Hydration

One of the standout features of polynucleotides is their ability to improve skin hydration. These molecules attract and retain water in the skin, making them an excellent choice for those with dry skin. Increased hydration not only plumps the skin, giving it a youthful glow, but also fortifies the skin barrier, reducing the risk of sensitivity and irritation.

3. Anti-Inflammatory Properties

Polynucleotides have been shown to exhibit anti-inflammatory effects, which are crucial in calming irritated or inflamed skin. This makes them suitable for sensitive skin or conditions like eczema or rosacea. By reducing inflammation, polynucleotides help create a more even skin tone and prevent long-term damage caused by chronic skin irritation.

4. Protection Against Free Radicals

As the skin is exposed to environmental aggressors, such as UV rays and pollution, it generates free radicals that can accelerate ageing and damage. Polynucleotides act as antioxidants, neutralising these harmful molecules and protecting the skin from oxidative stress. This protection supports long-term skin health by preventing premature ageing and damage at the cellular level.

Polynucleotides for Anti-Ageing: A Natural Solution

Ageing is an inevitable process, but how we care for our skin can make a significant difference in how our skin ages. The introduction of polynucleotides into skincare is a revolutionary step in non-invasive anti-ageing treatments. Unlike synthetic compounds or invasive procedures, polynucleotides offer a biologically compatible and natural approach to reversing the signs of ageing.

1. Collagen Stimulation and Skin Firmness

One of the major reasons for visible ageing is the loss of collagen over time. Collagen is responsible for keeping the skin firm and smooth. By stimulating collagen synthesis, polynucleotides help rebuild and restore this vital protein within the skin. As a result, the skin regains its firmness and elasticity, reducing the sagging and loss of volume typically associated with ageing.

2. Smoothening of Wrinkles and Fine Lines

The ability of polynucleotides to enhance skin regeneration also translates into the reduction of wrinkles and fine lines. As the skin renews itself more effectively, old, damaged cells are replaced with new, healthy ones. Over time, this leads to smoother skin and reduced depth and number of wrinkles.

3. Long-Lasting Skin Rejuvenation

Unlike short-term cosmetic treatments that provide only temporary effects, polynucleotides work at a cellular level to promote long-lasting rejuvenation. Regular use of polynucleotide-based treatments has been shown to continuously improve skin quality over time, making it a sustainable option for those looking to maintain youthful, healthy skin.

Polynucleotide Treatments: What to Expect

Polynucleotides can be introduced into your skincare routine, ranging from topical creams to more intensive medical treatments. Let’s take a closer look at how they can be applied for skin health and rejuvenation.

1. Topical Polynucleotide Serums and Creams

These are often included in high-quality skincare products designed to target ageing and hydration. When applied regularly, these topical treatments penetrate the upper layers of the skin, delivering hydration and stimulating repair at a cellular level.

2. Injectable Polynucleotide Treatments

For more profound results, injectable polynucleotides are available in dermatological settings. These are administered into the deeper layers of the skin, providing targeted rejuvenation for areas with severe signs of ageing or damage. The procedure is minimally invasive, and patients can expect noticeable skin texture, hydration, and firmness improvements within weeks.

3. Microneedling with Polynucleotides

Microneedling and applying polynucleotide serums can further enhance skin repair and regeneration. The process creates tiny punctures in the skin, allowing the polynucleotides to penetrate deeply and stimulate the healing process. This combination treatment is popular for addressing acne scars, fine lines, and pigmentation.

Brands Using Polynucleotides in Skincare

The skincare industry is rapidly embracing the benefits of polynucleotides, with several brands incorporating these powerful biopolymers into their product lines. Her are some examples of brands that have adopted polynucleotides for their skin health and rejuvenation properties.

1. Plinest

Plinest is a renowned brand that uses polynucleotides in its injectable treatments to promote skin regeneration and hydration. Their products are widely used in aesthetic clinics to improve skin quality, particularly in the face and neck areas. The Plinest line has gained popularity for offering long-lasting results in skin rejuvenation without more invasive procedures.

2. Rejuran

A major player in the Asian beauty market, Rejuran has developed a series of polynucleotide-based products, with its star offering being Rejuran Healer. This injectable treatment is designed to repair damaged skin, boost collagen production, and improve overall skin texture. It’s particularly effective for treating acne scars, fine lines, and uneven skin tone. Rejuran’s success has made polynucleotides more mainstream in countries like South Korea and Singapore, where anti-ageing and skin health are highly prioritised.

3. Derma 2 Bio

Derma 2.0 Bio is a leading brand specializing in polynucleotide-based skin revitalization solutions. Their injectable treatments are designed to stimulate collagen production, enhance skin elasticity, and improve overall skin quality. Widely recognized for its effectiveness in reducing wrinkles and restoring a youthful appearance, Derma 2.0 Bio is a popular choice in aesthetic clinics for facial and neck rejuvenation. The brand is celebrated for its commitment to providing safe and effective treatments with long-lasting results, offering a non-surgical approach to achieving radiant and healthy skin.

4. NucleoFill

Mastelli Aesthetics is an Italian brand known for its NucleoFill product line, which features polynucleotide-based treatments for skin bio-revitalisation. NucleoFill is available in both injectable and topical forms, offering solutions for skin hydration, elasticity, and rejuvenation. This brand is often used in aesthetic medicine for clients seeking a non-invasive way to achieve firmer, healthier-looking skin.

5. Philart by Croma

Philart is a leading brand specialising in polynucleotide-based skin revitalisation solutions. Their injectable treatments are designed to stimulate collagen production, enhance skin elasticity, and improve overall skin quality. Widely recognised for its effectiveness in reducing wrinkles and restoring a youthful appearance, Philart is a popular choice in aesthetic clinics for facial and neck rejuvenation. The brand is celebrated for its commitment to providing safe and effective treatments with long-lasting results, offering a non-surgical approach to achieving radiant and healthy skin.

Safety and Effectiveness of Polynucleotide-Based Treatments

Polynucleotides are generally considered safe for use in skincare, as they are derived from natural sources and are highly biocompatible. Clinical studies have demonstrated their efficacy in enhancing skin repair and promoting anti-ageing effects, with minimal side effects reported.

However, as with any treatment, it’s essential to consult a dermatologist to ensure that polynucleotides are appropriate for your skin type and concerns.

Frequently Asked Questions

What are polynucleotides used for in skincare?


Polynucleotides enhance skin repair, boost collagen production, and improve skin hydration. They effectively reduce wrinkles, improve skin elasticity, and address signs of ageing.

Can polynucleotides help with acne scars?


Yes, polynucleotides can help improve the appearance of acne scars by promoting skin regeneration and collagen production. This process smoothes the skin’s surface and reduces scar depth over time.

Are polynucleotide treatments safe?


Polynucleotide treatments are considered safe, especially when administered by trained professionals. They are biocompatible and pose minimal risk of allergic reactions or adverse side effects.

How soon can I see results from polynucleotide treatments?


Results from polynucleotide treatments can vary depending on the method of application. Topical treatments may show improvements within weeks, while injectable treatments can offer noticeable results within a few days to a few weeks.

Can polynucleotides be combined with other skincare treatments?


Yes, for enhanced results, polynucleotides can be used alongside other skincare treatments, such as microneedling, laser therapy, and hyaluronic acid fillers.

Is polynucleotide treatment suitable for sensitive skin?


Polynucleotides have anti-inflammatory properties, making them suitable for sensitive or inflamed skin. However, it’s always best to consult with a professional to ensure the treatment is right for your skin condition.

What results can I expect from Polynucleotide treatments?

Polynucleotide treatments typically lead to smoother, firmer, and more hydrated skin. While individual results may vary, many people notice improvements within a few weeks of treatment.

Are polynucleotides suitable for all skin types?

Yes, polynucleotide treatments are generally safe and effective for all skin types, including sensitive skin.

How long does it take to see results after a polynucleotide treatment?

Most people start seeing noticeable results within 2-4 weeks after treatment, although the full effects may take a bit longer to manifest.

What is the difference between polynucleotides and other skin rejuvenation treatments?

Unlike treatments like fillers or botox, which provide instant but temporary results, polynucleotides repair the skin at a cellular level, offering more long-term benefits.

Can polynucleotide treatments be combined with other procedures?

Yes, many people combine polynucleotide treatments with other skin rejuvenation techniques, such as microneedling or laser therapy, to enhance the overall results.

How many treatments are typically required for optimal results?

While this depends on individual skin conditions, most patients require 3-4 treatments spaced a few weeks apart for optimal results.

Conclusion

Polynucleotides represent a powerful and natural solution to skin health and rejuvenation. By harnessing the body’s own regenerative processes, they offer a sustainable way to repair damage, reduce the signs of ageing, and maintain a youthful glow. Whether used in topical products or more advanced dermatological treatments, polynucleotides are becoming a staple in modern skincare for those seeking long-term skin health and vitality.

model showing philart polynucleotide logo
Andy Taylor

I am a Consultant working in the NHS specialising in non-surgical aesthetic treatments.

Follow us on Facebook